Health Optimization Medicine · Charlotte, NC
Health Optimization Medicine in Charlotte
I am Daniel Tagge, MD, a board-certified family physician and North Carolina’s first physician fully certified to practice Health Optimization Medicine. HOMe is the clinical methodology inside my concierge longevity practice: a formal definition of health, and a method for interpreting your physiology over time, on top of standard medical assessment rather than in place of it. Accepted patients begin with the Precision Health Assessment, and in the Charlotte metro it happens in your home.
The methodology
A definition of health, and a method for working toward it
Medicine is precise about disease. It has been less precise about health, which is usually defined as the absence of disease. Health Optimization Medicine begins by defining it: an optimal physiologic state characterized by the absence of disease plus the balance of anabolic and catabolic processes in the body according to where you are in the life cycle. In plain terms, your body is always building and breaking down, the right balance changes across a lifetime, and health is that balance held well.
The method follows from the definition. Measure the information most likely to change a decision, starting with what you already have. Interpret it longitudinally, in the context of your history, your goals, the clinical evidence and standard medical assessment. When something meaningful is off and the evidence supports acting, intervene, reassess and refine.
Two limits keep it honest. The absence of disease does not mean every aspect of your physiology is where it should be. And a hypothesis about what could be optimized is not, on its own, a justification to treat.
The framework
The seven pillars of HOMe
Health Optimization Medicine organizes physiology into seven interacting systems. They are a map for interpretation, not a checklist of tests: which of them is measured, and how deeply, is decided for each patient.
Metabolism & Metabolomics
The small molecules the body produces as it makes energy and repairs itself: one view of what is happening biologically now, used when it adds to standard laboratory medicine.
Mitochondria & Cellular Energy
How cells make energy, and how that capacity relates to fatigue, performance and recovery.
Chronobiology
Circadian rhythm and its influence on hormones, metabolism, sleep and recovery.
Gut-Immune Health
Digestion, the microbiome, the gut barrier and the immune activity that sits alongside them.
Exposomics
The cumulative environmental load a person carries: diet, chemicals, metals, light and the rest, considered where it is relevant.
Epigenetics
How environment, behavior and exposure influence which genes are expressed over a lifetime.
Evolutionary Medicine
The physiology humans evolved with, read against the environment we live in now, as a lens for interpretation.

Written by
Daniel Tagge, MD
Board-certified family physician and founder of Tagge Health. Certified in Health Optimization Medicine.
About Dr. TaggeThe seven pillars
Every biological system I read
HOMe is built on seven biological pillars. Each one has its own page, written for the people I treat.
Positioning
How this is different
Where concierge longevity medicine sits beside conventional, preventive, functional and integrative medicine, and how the practice interprets physiology over time.
Read this areaFramework
Health Optimization Medicine
The clinical framework the practice works from. Measure, compare, balance across seven biological systems.
Read this areaPillars
Metabolism & Metabolomics.
Urinary organic acids read the upstream patterns of energy production, neurotransmitter balance, detoxification, and recovery.
Read this areaPillars
Mitochondria & Cellular Energy.
Mitochondria produce most of the energy every other function depends on. Aspects of that function can be assessed, and much of it responds to how you live.
Read this areaPillars
Gut-Immune Health.
The gut microbiome interacts extensively with immune, metabolic, and gastrointestinal physiology. Read the ecosystem as one system.
Read this areaPillars
Evolutionary Medicine.
Your biology was shaped by an environment that differs from the one you live in. Much of chronic disease can be read, in part, as that mismatch. This is the lens I read every other pillar through.
Read this areaPillars
Chronobiology.
Every hormone, immune function, and metabolic process runs on a circadian schedule. The disruption is measurable, and the consequences are systemic.
Read this areaPillars
Exposomics.
The cumulative environmental load a person carries can matter for physiology. Some of it can be measured, and I assess it when your history says it is relevant.
Read this areaPillars
Epigenetics.
The methylation cycle is the dial your environment turns. I read where it is stuck.
Read this area
Common questions about Health Optimization Medicine
Start here
Want this applied to your own physiology?
You start by applying. I read every application myself and follow up with you after review. You tell me what is going on. I tell you how I would approach it. You decide if I am the right physician for you.
Ready now? Apply to work with me.
Home visits in the Charlotte metro; virtual across North Carolina.