Available standalone

Methylation Panel.

Read the methylation cycle directly. The biomarkers that show where it's stuck.

By Genova Diagnostics · 10 biomarkers

Why it matters

Methylation runs detoxification, neurotransmitter synthesis, DNA repair, energy metabolism, and a meaningful slice of your cardiovascular risk. When the cycle slows, all five slow with it. This panel reads the cycle directly — methionine, SAM, SAH, homocysteine, the folate metabolites, and the cystathionine handoff — so the interpretation can point to the specific lever that moves it for you. It is one of the few advanced panels available outside the Precision Partnership as a standalone purchase.

What I read for

Homocysteine alone is not enough. I read it with the SAM/SAH ratio, the folate metabolites, and the cystathionine handoff to see where the cycle is bottlenecked. The point is to find the specific lever that moves it for you, not to chase a single number.

What it measures

Every marker in the panel.

See all 10 biomarkers

Methylation Cycle

  • Methionine
  • Homocysteine
  • Cystathionine
  • Cysteine
  • S-adenosylmethionine (SAM)
  • S-adenosylhomocysteine (SAH)
  • SAM/SAH ratio
  • 5-methyltetrahydrofolate (5-MTHF)
  • Folic acid
  • Folinic acid

Order the panel

Available standalone.

Kit ships within 2 business days. Your written interpretation arrives within 7 business days of the lab releasing results.

Included

  • The Genova Diagnostics Methylation Panel test kit.
  • Lab processing and the standard Genova report.
  • A written interpretation from Dr. Tagge, specific to your data.
  • A 30-minute review visit to walk through what the results mean.